A quick search for popular peptide and other compound protocols. See dosing, duration, side effects and other important guidelines before you start.
Tirzepatide
Reconstitution
With a 30 mg vial, 3 mL of bac water gives a clean 10 mg/mL where every titration step is a round number (2.5 mg is 25 units, 5 mg is 50, 10 mg is 100). Smaller vials take 1 to 2 mL.
Use bacteriostatic water as your diluent.
Add the water slowly, letting it run down the inside wall of the vial rather than firing it onto the powder.
Swirl gently to mix, then leave it to dissolve. Do not shake.
Give it a few minutes. The finished solution should be clear and colourless.
New to mixing peptides? Our general beginner’s guide to reconstitution walks through the basics that apply to any vial.
Suggested Protocol
Weeks 1 to 4: 2.5 mg
Weeks 5 to 8: 5 mg
Then step up by 2.5 mg every 4 weeks as needed: 7.5, 10, 12.5, up to 15 mg max
Recommended maintenance doses are 5, 10, or 15 mg
The 2.5 mg step is a starter dose, not a maintenance dose
If you are losing weight and feel fine at 5 mg or 7.5 mg, stay there
Only go up if progress stalls and you are tolerating the current dose
Dosing Detail
Start at 2.5 mg for a full 4 weeks. This dose is for letting your gut adjust, not for weight loss.
Move to 5 mg at week 5. From there, only increase by 2.5 mg at a time, never more often than every 4 weeks.
Maintenance lands at 5, 10, or 15 mg depending on response. Plenty of people hold at 5 or 10 mg long term.
Same day each week. Half-life is about 5 days.
Based on 2 mL of bac water.
Want a different syringe type or more detail? Open the full dose calculator.
Duration
A long-run protocol. Titrate over the first 3 to 5 months, then hold your maintenance dose for as long as it keeps working for you. Stopping tends to bring weight back, so plan your exit.
Notes
Inject subcutaneously and rotate sites weekly.
Nausea and early fullness are the common early effects and ease with slow titration.
Keep protein up and stay hydrated to protect muscle while losing weight.
Storage & Handling
Keep the powdered (lyophilized) vial in a cool, dark place. Refrigerate it for longer-term storage before mixing.
Once reconstituted and properly stored (refrigerated at 2 to 8°C and kept out of direct light), use the vial within 90 days.
Do not freeze a reconstituted vial, and keep it away from heat and sunlight.
If the solution turns cloudy, develops floating particles, or shows any other sign of degradation, stop using that vial.
