Skip to content Inauguração emGrand opening inInauguración en --d --h --m --s · Cadastro VIP ›· VIP sign-up ›· Registro VIP › Abrimos hoje · aguardeWe open today · hold onAbrimos hoy · aguarde Loja aberta! Entrar ›Store open! Enter ›¡Tienda abierta! Entrar ›
Eagle Pharma
Track order WhatsApp

KNOWLEDGE · COMPOUNDS

Epitalon

Also known as: Epithalon · Epithalamin · AEDG

LongevityPreclinicalPubMed records: 30count from PubMed, not curated
Ask Eagle AI about this compound

Overview

O Epithalon (Epitalon) é um tetrapeptídeo sintético (Ala-Glu-Asp-Gly) derivado do peptídeo pineal natural Epithalamina, desenvolvido pelo gerontologista russo Prof. Vladimir Khavinson. Sua principal ação é a ativação da telomerase, enzima que restaura o comprimento dos telômeros — as 'capas protetoras' dos cromossomos que encurtam com cada divisão celular e estão correlacionadas com o envelhecimento biológico. Também restaura a produção de melatonina pela glândula pineal. Original in PT-BR

Epitalon is catalogued under Longevity. 19 Eagle articles in this library reference this compound.

Category
Longevity
Research stage
Preclinical — Pré-Clínico (Extensivo em modelo animal) Original in PT-BR
PubMed records
30 (count from PubMed, not curated)
Eagle articles on this compound
19 Eagle articles

Mechanism

Ativa telomerase → alongamento de telômeros. Restaura produção de melatonina pineal Original in PT-BR

O Epithalon atua em dois mecanismos anti-aging: (1) Ativa a subunidade catalítica da telomerase (hTERT), permitindo a adição de sequências TTAGGG aos telômeros. Telômeros curtos sinalizam senescência celular e apoptose; ao restaurar seu comprimento, o Epithalon pode retardar o envelhecimento celular. (2) Restaura a função da glândula pineal, que naturalmente calcifica com a idade, normalizando a produção circadiana de melatonina — hormônio crucial para ritmo circadiano, imunidade e neuroproteção. Original in PT-BR

Eagle articles on this compound

Chemical information

CAS
307297-39-8
Molecular formula
C₁₄H₂₂N₄O₉
Molecular weight
390.35 g/mol
Sequence
Ala-Glu-Asp-Gly
Amino acids
4 counted from the sequence above
Solubility
Água bacteriostática Original in PT-BR
Stability
Estável reconstituído por 28 dias refrigerado Original in PT-BR
Half-life
~2 horas Original in PT-BR
Bioavailability
Alta (SC) Original in PT-BR
Onset
Ciclos de 10-20 dias; efeitos em meses Original in PT-BR
Routes
SC

Research references

No individual dosing recommendation is given. Values are as recorded in the source, with species and route stated where known.

Third-party research score

55/ 100

Score assigned by the imported source, on its own scale and with no published methodology. Eagle does not compute it, does not verify it and does not endorse it. It appears here to preserve the record, not as an assessment.

  • Ativação de telomerase e alongamento de telômeros em fibroblastos humanos Original in PT-BR

    PMID: 12937682Year: 2003Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • Restauração da secreção de melatonina em idosos após ciclo de Epithalon Original in PT-BR

    PMID: 14615538Year: 2003Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • Aumento de longevidade em 15-20% em modelos de roedores Original in PT-BR

    PMID: 12578824Year: 2003Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

Safety

Commonly reported

  • Leve desconforto no local da injeção

Serious

  • Sem efeitos adversos graves documentados nos estudos disponíveis

Contraindications

  • Cânceres ativos (telomerase pode teoricamente favorecer células tumorais)

Warnings

  • Maioria dos estudos são de grupos de pesquisa russos — replicação independente limitada

Original in PT-BR — This text was written in Brazilian Portuguese and is shown as recorded. Open the PT-BR page for Epitalon.

Lab tests named in the source

  • Melatonina (se disponível)
  • IGF-1
  • PCR (inflamação)

The source names the tests and nothing else: no reference values and no thresholds. None were added here. Interpreting a result is a clinical act and is not offered on this page.

Reported protocols

Recorded in the imported source as community protocols. They are NOT Eagle protocols, were not reviewed by Eagle, and are not a dosing recommendation, a prescription or clinical guidance. Values appear exactly as recorded, in the language they were written in.

Dosing summary as recorded

Dose Padrão
5-10mg/dia SC Original in PT-BR
Protocolo
10-20 dias, repetir a cada 4-6 meses Original in PT-BR
Frequência
1x/dia (ciclos) Original in PT-BR
UI Seringa
10UI = 500mcg (10mg/2mL) Original in PT-BR

Vial sizes: 10mg · 50mg — Peptide Calculator

Interactions

These relations come from the imported reference material, which records one label and one comment per pair and no source: no PMID, no population or model, no evidence type and no degree of certainty. Eagle did not verify them and does not endorse them. «Compatible», «Caution» and «Avoid» are the imported material's wording, not an Eagle authorisation or prohibition, and none of this is medical advice.

Reported synergy

Compatible

Related

View all (19)

← Back to knowledge area