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KNOWLEDGE · COMPOUNDS

Thymalin

ImmunityPreclinicalPubMed records: 30count from PubMed, not curated
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Overview

O Thymalin é um dipeptídeo (Glu-Trp) extraído do timo bovino, desenvolvido na Rússia pelo professor Vladimir Khavinson. Atua como regulador da função tímica, modulando a maturação e diferenciação de linfócitos T. Estudos observacionais de longo prazo sugerem efeitos de longevidade significativos. Original in PT-BR

Thymalin is catalogued under Immunity. 0 Eagle articles in this library reference this compound.

Category
Immunity
Research stage
Preclinical — Pré-Clínico (estudos observacionais russos) Original in PT-BR
PubMed records
30 (count from PubMed, not curated)
Eagle articles on this compound
0 Eagle articles

Mechanism

Peptídeo do timo — regulação imune + longevidade via modulação T-cell Original in PT-BR

O Thymalin é um biopeptídeo regulador que restaura a função do timo, glândula que involui progressivamente com a idade. Seu mecanismo principal envolve a regulação da diferenciação e maturação de linfócitos T no timo, restaurando a diversidade do repertório imune que declina com o envelhecimento (imunossenescência). Em estudos do grupo Khavinson, pacientes idosos que receberam ciclos de Thymalin mostraram redução de mortalidade e aumento de longevidade em acompanhamento de 6+ anos. O mecanismo proposto envolve restauração epigenética da expressão gênica tímica e modulação de citocinas (redução de IL-6/TNF-α inflamatórias, aumento de IL-2/IL-10 regulatórias). Dados são predominantemente de estudos russos com metodologia limitada. Original in PT-BR

Chemical information

CAS
60842-46-8
Molecular formula
C₁₆H₁₉N₃O₅
Molecular weight
333.34 g/mol
Sequence
EW (Glu-Trp) Original in PT-BR
Amino acids
Not recorded in the source.
Solubility
Solúvel em água e soluções salinas Original in PT-BR
Stability
Liofilizado: estável a temperatura ambiente. Solução: usar imediatamente Original in PT-BR
Half-life
Curta (minutos a horas) Original in PT-BR
Bioavailability
Alta (IM/SC) Original in PT-BR
Onset
5-10 dias (modulação imune) Original in PT-BR
Routes
IM · SC

Research references

No individual dosing recommendation is given. Values are as recorded in the source, with species and route stated where known.

Third-party research score

45/ 100

Score assigned by the imported source, on its own scale and with no published methodology. Eagle does not compute it, does not verify it and does not endorse it. It appears here to preserve the record, not as an assessment.

  • Thymalin + Epithalon reduziram mortalidade em 50% em seguimento de 6 anos em idosos Original in PT-BR

    PMID: 12851085Year: 2003Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • Restauração de parâmetros imunológicos em idosos com imunossenescência Original in PT-BR

    PMID: 14615537Year: 2003Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

Safety

Commonly reported

  • Dor no local da injeção (IM)
  • Leve febre transitória (raro — sinal de ativação imune)

Serious

  • Sem efeitos adversos graves reportados na literatura disponível

Contraindications

  • Doenças autoimunes ativas (pode exacerbar)
  • Transplante de órgãos (rejeição)
  • Gravidez/amamentação

Warnings

  • CONFLITO com imunossupressores (golimumabe, metotrexato, etc.)
  • Estimula T-cells — pode antagonizar terapia anti-TNF
  • Dados predominantemente de estudos russos com metodologia variável

Original in PT-BR — This text was written in Brazilian Portuguese and is shown as recorded. Open the PT-BR page for Thymalin.

Lab tests named in the source

  • Hemograma completo com diferencial
  • Subpopulações de linfócitos (CD4/CD8)
  • Imunoglobulinas (IgA/IgG/IgM)
  • IL-6
  • PCR

The source names the tests and nothing else: no reference values and no thresholds. None were added here. Interpreting a result is a clinical act and is not offered on this page.

Reported protocols

Recorded in the imported source as community protocols. They are NOT Eagle protocols, were not reviewed by Eagle, and are not a dosing recommendation, a prescription or clinical guidance. Values appear exactly as recorded, in the language they were written in.

Dosing summary as recorded

Dose Padrão
10mg IM/dia Original in PT-BR
Duração do Ciclo
10 dias Original in PT-BR
Frequência dos Ciclos
A cada 6 meses Original in PT-BR
Via Preferencial
IM (intramuscular) Original in PT-BR

Vial sizes: 10mg — Peptide Calculator

Interactions

These relations come from the imported reference material, which records one label and one comment per pair and no source: no PMID, no population or model, no evidence type and no degree of certainty. Eagle did not verify them and does not endorse them. «Compatible», «Caution» and «Avoid» are the imported material's wording, not an Eagle authorisation or prohibition, and none of this is medical advice.

Reported synergy

Compatible

Avoid

  • Imunossupressores (anti-TNF)

    CONFLITO DIRETO — Thymalin estimula imunidade que anti-TNF suprime. Risco de flare autoimune Original in PT-BR

Related

No Eagle article in this library references this compound yet.

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