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KNOWLEDGE · COMPOUNDS

Humanin

LongevityPreclinicalPubMed records: 120count from PubMed, not curated
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Overview

O Humanin é um micropeptídeo de 24 aminoácidos codificado pelo DNA mitocondrial (mtDNA), descoberto em 2001 no contexto de pesquisa sobre Alzheimer. É o primeiro peptídeo mitocondrial identificado com ação citoprotetora — protege células contra apoptose, melhora a resistência à insulina e possui propriedades neuroprotetoras significativas. Seus níveis diminuem com a idade, correlacionando-se com o envelhecimento celular. Original in PT-BR

Humanin is catalogued under Longevity. 0 Eagle articles in this library reference this compound.

Category
Longevity
Research stage
Preclinical — Pré-Clínico (Pesquisa ativa) Original in PT-BR
PubMed records
120 (count from PubMed, not curated)
Eagle articles on this compound
0 Eagle articles

Mechanism

Peptídeo derivado do DNA mitocondrial — neuroproteção, anti-apoptose, melhora da resistência à insulina Original in PT-BR

O Humanin exerce seus efeitos através de múltiplas vias: (1) Liga-se ao receptor FPRL1/FPRL2, ativando cascatas anti-apoptóticas (via STAT3 e ERK). (2) Interage com a proteína pró-apoptótica BAX, impedindo sua translocação para a mitocôndria. (3) Melhora a sinalização de insulina e reduz a resistência insulínica via interação com o receptor IGFBP-3. (4) Exerce neuroproteção contra beta-amilóide e estresse oxidativo, relevante para doenças neurodegenerativas. Como peptídeo mitocondrial, seus níveis refletem a saúde mitocondrial geral. Original in PT-BR

Chemical information

CAS
330936-69-1
Molecular formula
Peptídeo de 24aa Original in PT-BR
Molecular weight
~2.687 Da
Sequence
MAPRGFSCLLLLTSEIDLPVKRRA
Amino acids
24 counted from the sequence above
Solubility
Água bacteriostática, PBS Original in PT-BR
Stability
Liofilizado: -20°C. Reconstituído: 14 dias 2-8°C Original in PT-BR
Half-life
Variável (~horas) Original in PT-BR
Bioavailability
Moderada (SC) Original in PT-BR
Onset
Semanas (efeitos clínicos) Original in PT-BR
Routes
SC

Research references

No individual dosing recommendation is given. Values are as recorded in the source, with species and route stated where known.

Third-party research score

60/ 100

Score assigned by the imported source, on its own scale and with no published methodology. Eagle does not compute it, does not verify it and does not endorse it. It appears here to preserve the record, not as an assessment.

  • Primeira identificação do Humanin como peptídeo mitocondrial neuroprotetor Original in PT-BR

    PMID: 11551976Year: 2001Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • Proteção contra toxicidade beta-amilóide via vias anti-apoptóticas Original in PT-BR

    PMID: 23602601Year: 2013Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • Melhora da resistência à insulina e metabolismo de glicose em modelos animais Original in PT-BR

    PMID: 28622073Year: 2017Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

Safety

Commonly reported

  • Dados de segurança humana limitados

Serious

  • Sem efeitos adversos graves documentados em estudos pré-clínicos

Contraindications

  • Sem dados suficientes para contraindicações formais

Warnings

  • Uso puramente experimental
  • Dados de segurança humana muito limitados

Original in PT-BR — This text was written in Brazilian Portuguese and is shown as recorded. Open the PT-BR page for Humanin.

Lab tests named in the source

  • Glicemia de jejum
  • Insulina
  • HOMA-IR
  • Biomarcadores mitocondriais

The source names the tests and nothing else: no reference values and no thresholds. None were added here. Interpreting a result is a clinical act and is not offered on this page.

Reported protocols

Recorded in the imported source as community protocols. They are NOT Eagle protocols, were not reviewed by Eagle, and are not a dosing recommendation, a prescription or clinical guidance. Values appear exactly as recorded, in the language they were written in.

Dosing summary as recorded

Dose Pesquisada
1-5mg/dia SC Original in PT-BR
Range
1-5mg/dia Original in PT-BR
Status
Pesquisa — sem protocolo estabelecido Original in PT-BR

Vial sizes: 5mg — Peptide Calculator

Interactions

These relations come from the imported reference material, which records one label and one comment per pair and no source: no PMID, no population or model, no evidence type and no degree of certainty. Eagle did not verify them and does not endorse them. «Compatible», «Caution» and «Avoid» are the imported material's wording, not an Eagle authorisation or prohibition, and none of this is medical advice.

Reported synergy

Compatible

Related

No Eagle article in this library references this compound yet.

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