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KNOWLEDGE · COMPOUNDS

VIP

LongevityPreclinicalPubMed records: 200count from PubMed, not curated
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Overview

O VIP (Vasoactive Intestinal Peptide) é um neuropeptídeo de 28 aminoácidos originalmente isolado do intestino delgado, mas com distribuição ampla no sistema nervoso central e periférico. Atua como poderoso neuroimunomodulador e anti-inflamatório, sendo utilizado em pesquisa para condições inflamatórias crônicas, CIRS (Chronic Inflammatory Response Syndrome) e como neuroprotetor. Tem papel na regulação do ritmo circadiano, função imune e vasodilatação. Original in PT-BR

VIP is catalogued under Longevity. 0 Eagle articles in this library reference this compound.

Category
Longevity
Research stage
Preclinical — Pré-Clínico (Biologia extensa, uso clínico para CIRS) Original in PT-BR
PubMed records
200 (count from PubMed, not curated)
Eagle articles on this compound
0 Eagle articles

Mechanism

Neuropeptídeo de 28 aminoácidos — neuroimunomodulação, vasodilatação, relaxamento de músculo liso, anti-inflamatório Original in PT-BR

O VIP atua através dos receptores VPAC1 e VPAC2, presentes em diversos tecidos: (1) ANTI-INFLAMAÇÃO: suprime produção de TNF-α, IL-6 e IL-12 por macrófagos; inibe ativação de NF-κB; promove geração de células T regulatórias (Treg). (2) NEUROPROTEÇÃO: protege neurônios contra glutamato, beta-amilóide e estresse oxidativo; modula neurotransmissão. (3) VASODILATAÇÃO: relaxa músculo liso vascular e bronquial. (4) IMUNOMODULAÇÃO: promove tolerância imune sem imunossupressão. (5) REGULAÇÃO CIRCADIANA: expresso no núcleo supraquiasmático, regula o relógio biológico. Sua meia-vida extremamente curta limita uso sistêmico, mas a via intranasal permite acesso ao SNC. Original in PT-BR

Chemical information

CAS
37221-79-7
Molecular formula
C₁₄₇H₂₃₇N₄₃O₄₃S
Molecular weight
3326.83 g/mol
Sequence
HSDAVFTDNYTRLRKQMAVKKYLNSILN
Amino acids
28 counted from the sequence above
Solubility
Água bacteriostática, soro fisiológico Original in PT-BR
Stability
Liofilizado: -20°C. Reconstituído: 7-14 dias 2-8°C. Sensível a degradação Original in PT-BR
Half-life
~1-2 minutos (muito curta — degradação rápida por DPP-IV) Original in PT-BR
Bioavailability
Moderada (SC), variável (intranasal) Original in PT-BR
Onset
Minutos (vasodilatação), semanas (imunomodulação) Original in PT-BR
Routes
SC · Intranasal

Research references

No individual dosing recommendation is given. Values are as recorded in the source, with species and route stated where known.

Third-party research score

60/ 100

Score assigned by the imported source, on its own scale and with no published methodology. Eagle does not compute it, does not verify it and does not endorse it. It appears here to preserve the record, not as an assessment.

  • Revisão seminal do VIP como neuropeptídeo com amplas funções imunológicas Original in PT-BR

    PMID: 1313556Year: 1992Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • VIP suprime inflamação e promove tolerância imune em modelos autoimunes Original in PT-BR

    PMID: 16543370Year: 2006Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • Protocolo de uso de VIP intranasal para CIRS com resultados positivos Original in PT-BR

    PMID: 28392244Year: 2017Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

Safety

Commonly reported

  • Rubor facial (vasodilatação)
  • Hipotensão transitória
  • Diarreia (doses altas)

Serious

  • Hipotensão significativa em doses altas
  • Taquicardia reflexa

Contraindications

  • Hipotensão
  • Diarreia crônica
  • Tumores produtores de VIP (VIPoma)

Warnings

  • Meia-vida muito curta — efeito local/transitório
  • Via intranasal preferida para ação no SNC

Original in PT-BR — This text was written in Brazilian Portuguese and is shown as recorded. Open the PT-BR page for VIP.

Lab tests named in the source

  • PCR
  • TGF-β1
  • C4a
  • MSH (se disponível)
  • VIP sérico

The source names the tests and nothing else: no reference values and no thresholds. None were added here. Interpreting a result is a clinical act and is not offered on this page.

Reported protocols

Recorded in the imported source as community protocols. They are NOT Eagle protocols, were not reviewed by Eagle, and are not a dosing recommendation, a prescription or clinical guidance. Values appear exactly as recorded, in the language they were written in.

Dosing summary as recorded

Dose SC
50-100mcg/dia Original in PT-BR
Dose Intranasal
50mcg/dose Original in PT-BR
Via preferida
Intranasal (acesso SNC) Original in PT-BR
UI Seringa
5UI = 50mcg (5mg/5mL SC) Original in PT-BR

Vial sizes: 5mg — Peptide Calculator

Interactions

These relations come from the imported reference material, which records one label and one comment per pair and no source: no PMID, no population or model, no evidence type and no degree of certainty. Eagle did not verify them and does not endorse them. «Compatible», «Caution» and «Avoid» are the imported material's wording, not an Eagle authorisation or prohibition, and none of this is medical advice.

Compatible

Caution

Related

No Eagle article in this library references this compound yet.

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