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KNOWLEDGE · COMPOUNDS

DSIP

CognitivePreclinicalPubMed records: 50count from PubMed, not curated
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Overview

O DSIP (Peptídeo Indutor de Sono Delta) é um nonapeptídeo que promove sono profundo de ondas delta (estágio 3-4 NREM), o período mais restaurador do sono onde ocorre o pico de liberação de GH, consolidação de memória e reparo celular. Também modula o eixo cortisol/ACTH, reduzindo estresse. Original in PT-BR

DSIP is catalogued under Cognitive. 13 Eagle articles in this library reference this compound.

Category
Cognitive
Research stage
Preclinical — Pré-Clínico (dados humanos limitados) Original in PT-BR
PubMed records
50 (count from PubMed, not curated)
Eagle articles on this compound
13 Eagle articles

Mechanism

Promove sono delta profundo + modula cortisol + aumenta GH noturno Original in PT-BR

O DSIP foi isolado do sangue de coelhos durante o sono de ondas lentas. Atua em múltiplos sistemas: (1) Promoção de sono delta — aumenta duração e qualidade do sono de ondas lentas (estágios N3/N4), o período mais restaurador; (2) Modulação do eixo HPA — reduz cortisol e normaliza o ritmo circadiano de ACTH, com efeitos anti-estresse; (3) Aumento de GH noturno — o sono delta é quando ocorre ~75% da liberação diária de GH, portanto melhorar sono delta amplifica indiretamente a liberação de GH; (4) Modulação de serotonina e melatonina — contribui para a regulação do ritmo circadiano. O DSIP não é sedativo — ele restaura o padrão natural de sono, diferente de hipnóticos que forçam sono não-fisiológico. Original in PT-BR

Eagle articles on this compound

Chemical information

CAS
62568-57-4
Molecular formula
C₃₅H₄₈N₁₀O₁₅
Molecular weight
848.82 g/mol
Sequence
WAGGDASGE
Amino acids
9 counted from the sequence above
Solubility
Solúvel em água bacteriostática Original in PT-BR
Stability
Liofilizado: estável a -20°C. Reconstituído: 14 dias a 2-8°C Original in PT-BR
Half-life
~15 minutos Original in PT-BR
Bioavailability
Alta (SC) Original in PT-BR
Onset
30-60 minutos (indução de sono) Original in PT-BR
Routes
SC

Research references

No individual dosing recommendation is given. Values are as recorded in the source, with species and route stated where known.

Third-party research score

50/ 100

Score assigned by the imported source, on its own scale and with no published methodology. Eagle does not compute it, does not verify it and does not endorse it. It appears here to preserve the record, not as an assessment.

  • Caracterização do DSIP como promotor de sono de ondas lentas delta Original in PT-BR

    PMID: 7077352Year: 1982Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • DSIP normaliza ritmo de cortisol/ACTH — efeito anti-estresse Original in PT-BR

    PMID: 2867518Year: 1986Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • Confirmação de que sono delta é o principal período de liberação de GH Original in PT-BR

    PMID: 6138954Year: 1984Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

Safety

Commonly reported

  • Sonolência residual matinal (dose alta)
  • Sonhos vívidos

Serious

  • Sem efeitos adversos graves reportados

Contraindications

  • Apneia do sono não tratada
  • Gravidez/amamentação

Warnings

  • Não combinar com outros sedativos/hipnóticos inicialmente
  • Meia-vida curta — aplicar 30min antes de dormir
  • Tolerância possível com uso diário prolongado

Original in PT-BR — This text was written in Brazilian Portuguese and is shown as recorded. Open the PT-BR page for DSIP.

Lab tests named in the source

  • Cortisol matinal
  • IGF-1 (avaliação indireta de GH)
  • Melatonina (se disponível)

The source names the tests and nothing else: no reference values and no thresholds. None were added here. Interpreting a result is a clinical act and is not offered on this page.

Reported protocols

Recorded in the imported source as community protocols. They are NOT Eagle protocols, were not reviewed by Eagle, and are not a dosing recommendation, a prescription or clinical guidance. Values appear exactly as recorded, in the language they were written in.

Dosing summary as recorded

Dose Padrão
100-200mcg SC Original in PT-BR
Frequência
1x/dia (pré-sono) Original in PT-BR
Timing
30 minutos antes de dormir Original in PT-BR
Ciclo
2-4 semanas ON / 1-2 OFF Original in PT-BR
UI (5mg/2mL)
4UI = 100mcg / 8UI = 200mcg Original in PT-BR

Vial sizes: 5mg — Peptide Calculator

Interactions

These relations come from the imported reference material, which records one label and one comment per pair and no source: no PMID, no population or model, no evidence type and no degree of certainty. Eagle did not verify them and does not endorse them. «Compatible», «Caution» and «Avoid» are the imported material's wording, not an Eagle authorisation or prohibition, and none of this is medical advice.

Reported synergy

Compatible

Caution

Related

View all (13)

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