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KNOWLEDGE · COMPOUNDS

MOTS-C

MetabolicClinical trialsPubMed records: 80count from PubMed, not curated
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Overview

O MOTS-c é um peptídeo de 16 aminoácidos codificado pelo DNA mitocondrial, sendo o primeiro hormônio mitocondrial identificado. Atua como mimético de exercício, ativando a via AMPK para melhorar sensibilidade insulínica, oxidação de ácidos graxos e metabolismo energético celular. Original in PT-BR

MOTS-C is catalogued under Metabolic. 20 Eagle articles in this library reference this compound.

Category
Metabolic
Research stage
Clinical trials — Ensaios Clínicos (Fase I RCT) Original in PT-BR
PubMed records
80 (count from PubMed, not curated)
Eagle articles on this compound
20 Eagle articles

Mechanism

Ativador de AMPK — mimetiza sinais moleculares do exercício físico Original in PT-BR

O MOTS-c é derivado do gene 12S rRNA mitocondrial e funciona como um sinalfactor mitocondrial endógeno. Seu mecanismo principal envolve a ativação da quinase AMPK (AMP-activated protein kinase), o sensor metabólico central da célula. Ao ativar AMPK, o MOTS-c reproduz os efeitos moleculares do exercício aeróbico: aumento da captação de glicose independente de insulina, maior oxidação de ácidos graxos, biogênese mitocondrial e redução de lipogênese hepática. Estudos demonstram que o MOTS-c também regula o metabolismo do folato e da metionina, afetando a via de síntese de purinas e a epigenética celular. Em modelos animais, a suplementação de MOTS-c mimetiza os benefícios metabólicos do exercício físico, inclusive em animais sedentários. Original in PT-BR

Eagle articles on this compound

Chemical information

CAS
1627580-64-6
Molecular formula
C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight
2174.64 g/mol
Sequence
MRWQEMGYIFYPRKLR
Amino acids
16 counted from the sequence above
Solubility
Água bacteriostática, soro fisiológico Original in PT-BR
Stability
Estável quando liofilizado a -20°C. Reconstituído: 14 dias a 2-8°C Original in PT-BR
Half-life
~4-6 horas Original in PT-BR
Bioavailability
Alta (SC) Original in PT-BR
Onset
1-2 semanas (metabólico), dias (energia) Original in PT-BR
Routes
SC

Research references

No individual dosing recommendation is given. Values are as recorded in the source, with species and route stated where known.

Third-party research score

70/ 100

Score assigned by the imported source, on its own scale and with no published methodology. Eagle does not compute it, does not verify it and does not endorse it. It appears here to preserve the record, not as an assessment.

  • Descoberta do MOTS-c como hormônio mitocondrial com efeitos metabólicos amplos Original in PT-BR

    PMID: 25738459Year: 2015Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • MOTS-c é regulado positivamente pelo exercício e reverte declínio físico associado à idade Original in PT-BR

    PMID: 31462508Year: 2019Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • Benefícios além do metabolismo — melhora saúde óssea via TGF-β Original in PT-BR

    PMID: 30247852Year: 2018Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

  • Revisão abrangente do papel de peptídeos mitocondriais no envelhecimento Original in PT-BR

    PMID: 31982306Year: 2020Species: Not recorded as a structured field in the source.Route: Not recorded as a structured field in the source.Duration: Not recorded as a structured field in the source.Purpose: Not recorded as a structured field in the source.

Safety

Commonly reported

  • Rubor facial transitório
  • Leve sensação de calor após injeção
  • Hipoglicemia leve em jejum (raro)

Serious

  • Sem efeitos adversos graves reportados em estudos humanos iniciais

Contraindications

  • Hipoglicemia severa
  • Gravidez/amamentação
  • Diabetes tipo 1 não controlada

Warnings

  • Monitorar glicemia em diabéticos
  • Pode potencializar efeitos hipoglicemiantes de metformina

Original in PT-BR — This text was written in Brazilian Portuguese and is shown as recorded. Open the PT-BR page for MOTS-C.

Lab tests named in the source

  • Glicemia de jejum
  • HbA1c
  • Insulina de jejum (HOMA-IR)
  • Perfil lipídico
  • Função hepática (ALT/AST)

The source names the tests and nothing else: no reference values and no thresholds. None were added here. Interpreting a result is a clinical act and is not offered on this page.

Reported protocols

Recorded in the imported source as community protocols. They are NOT Eagle protocols, were not reviewed by Eagle, and are not a dosing recommendation, a prescription or clinical guidance. Values appear exactly as recorded, in the language they were written in.

Dosing summary as recorded

Dose Padrão
5-10mg SC Original in PT-BR
Frequência
3-5x por semana Original in PT-BR
Timing
Manhã (jejum ou pré-treino) Original in PT-BR
Ciclo
8-12 semanas ON / 4 OFF Original in PT-BR
UI (20mg/2mL)
10UI = 1mg / 50UI = 5mg Original in PT-BR

Vial sizes: 20mg · 40mg — Peptide Calculator

Interactions

This section brings together two origins. The ones Eagle wrote come from its own curated library, one by one; the rest come from the imported reference material, which records one label and one comment per pair and no source. Neither kind carries a PMID, a population or model, or a degree of certainty. Eagle did not verify the imported ones and does not endorse them. «Compatible», «Caution» and «Avoid» are not an Eagle authorisation or prohibition, and none of this is medical advice.

Reported synergy

Compatible

Caution

Related

View all (20)

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